Kangeyam Institute of Pharmaceutical Sciences and Research
Pharmaceutical Chemistry
Heal with Science

Definition

Pharmaceutical Chemistry involves the study of drug design, synthesis, analysis, and development. It blends basic chemistry and pharmacology to understand how chemical compounds can be used in the treatment of disease.

Content Overview

This subject provides the foundation for understanding the chemical aspects of drug molecules, including their structure-activity relationships (SAR), chemical stability, and synthesis. It forms the basis for drug development and quality control.

Medicinal Chemistry

Focuses on the design and chemical synthesis of drugs. Studies structure-activity relationships (SAR) to enhance drug effectiveness.

Organic Chemistry

Involves the study of carbon-based compounds and reactions used in drug synthesis.

Inorganic Chemistry

Deals with non-carbon elements and their compounds used in pharmaceutical formulations, like iron supplements and antacids.

Biochemistry

Explores chemical processes in living organisms. Helps understand enzyme functions, metabolism, and drug interactions.

Drug Synthesis and Analysis

Teaches how to chemically create drugs and ensure their identity and purity through various analytical methods.

Structure-Activity Relationships (SAR)

Examines how changes in chemical structure affect the biological activity of a drug molecule.

Pharmaceutical Analysis


Definition

Pharmaceutical Analysis is the branch of chemistry that deals with the qualitative and quantitative determination of drugs and pharmaceutical substances.

Content Overview

It focuses on the analytical techniques and instruments used to ensure the purity, quality, and standardization of drugs. This subject is vital in quality control and quality assurance in the pharmaceutical industry.

Titrimetric & Gravimetric Analysis

Quantitative methods to determine drug concentration using chemical reactions (acid-base, redox) or mass measurements.

Chromatographic Techniques

TLC, HPLC, and GC are methods to separate and analyze components in a mixture for purity and concentration.

UV-Vis, IR, NMR & Mass Spectroscopy

Techniques like UV-Vis, IR, NMR, and MS help identify molecular structure, functional groups, and purity of compounds.

Validation of Analytical Methods

Ensures accuracy, precision, reproducibility, and reliability of procedures used for pharmaceutical analysis.

Quality Control for Dosage Forms

Includes uniformity, dissolution, hardness, friability, and other tests to ensure consistent quality of drug products.

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